OPN、CD44v6在卵巢浆液性囊腺癌组织中表达的意义

Expression of osteopontin and CD44v6 in ovarian serous cystadenocarcinoma

目的:探讨OPN及其受体CD44v6在卵巢浆液性囊腺癌组织中的表达及其临床意义。方法:采用免疫组化技术分别检测10例正常卵巢组织、10例卵巢浆液性囊腺瘤组织、20例卵巢交界性浆液性囊腺瘤组织、40例卵巢浆液性囊腺癌组织中OPN和CD44v6的表达。结果:卵巢浆液性囊腺癌组织中OPN和CD44v6阳性表达率分别为80.00%(32/40)和75.00%(30/40),显著高于正常卵巢组织、卵巢浆液性囊腺瘤组织和卵巢交界性浆液性囊腺瘤组织(P<0.01)。卵巢癌组织中OPN、CD44v6的阳性表达率与临床分期及有无淋巴结转移有关,而与患者年龄及病理分级无关。且OPN和CD44v6的表达呈正相关(rs=0.58,P<0.01)。结论:OPN、CD44v6可能与卵巢浆液性囊腺癌的发生发展及转移相关,联合检测两者的表达可作为反映卵巢癌恶性程度和预后的参考指标。

Objective ： To examine the expression of osteopontin-dependent receptor CD44v6 in ovarian serous cystadenoearcinoma tissues and the clinical significance. Methods： Immunohistochemical S-P method was used to detect the expression of osteopontin and CD44v6 in 10 cases of normal ovarian tissue, 10 ovarian serous cystadenonm,20 ovary borderline serous cystadenoma and 40 ovarian serous cystadenocarciuoma. Results ： In ovarian serous cystadenocareinoma,the positive expression of osteopontin and CD44v6 was 80.00% （32/40） and 75.00% （ 30/40 ） , respectively,which was significantly higher than that of normal ovarian tissues, ovarian serous cystadenoma and borderline serous cystadenoma （P 〈 0.01 ）. The positive expression of hoth factors was associated with the clinical stage,presence or absence of lymph node metastasis,but was unparallel to the ages and pathology grading. Additionally, the expression of osteopontin was positively correlated with that of CD44v6（ rs =0.58 ,P 〈 0.01 ）. Conclusion：Osteopontin and CD44v6 may be involved in the genesis, development and metastasis of ovarian serous cystadenocarcinoma. The two factors detected in combination may serve as a biomarker to evaluate the progress and prognosis of this tumor.