三联疗法根除幽门螺杆菌的疗效观察

Observation of the Curative Effect of the Triad Therapy in Addition to Helicobacter Pylori

目的:评估左氧氟沙星为基础的三联治疗方案治疗幽门螺杆菌(helicobacter pylori,HP)感染的疗效及安全性。方法:对264例经胃镜检查和病理诊断慢性胃炎、胃溃疡的患者,随机分为治疗组和对照组各132例,治疗组给予左氧氟沙星、奥美拉唑、阿莫西林治疗;对照组给予奥美拉唑、克拉霉素、阿莫西林治疗,疗程均为10 d。结果:治疗组HP根除率为91.67%,对照组HP根除率为83.33%,两组治愈率差异均无统计学意义(P>0.05)。结论:左氧氟沙星联合奥美拉唑、阿莫西林是一种安全、疗效高、耐受性好,也是当前根除幽门螺杆菌首选的一线治疗方案。

Objective：Be based on Levofloxaein, to evaluate the curative effect and security of treating helieobacter pylofi with the treatment of tfigeminy. Methods： Cheek-up 264 patients with gastroseopy and pathological diagnosis of chronic gastritis, gastric ulcer patients were randomly divided into treatment and control groups with 132 cases respectively, the treatment of levofloxacin group, omeprazole, amoxiciUin treatment. In the control group given omeprazole, clarithromycin and amoxicillin treatment, treatment of 10d. Restilts： Hp eradication rate was 91.67% in the treatment group, 83.33% in the control group, the rate difference between the two groups were not significant （P 〉 0.05 ）. Conclusions： the Joint omeprazole and amoxicillin are safe, high effective, with good tolerance, and the eradication of Helieobaeter pylori is the current preferred first-line treatment.