胺碘酮治疗慢性心力衰竭合并室性心律失常的临床观察

Clinical investigation of amiodarone in the treatment of chronic heart failure with ventricular arrhythmias

目的探讨胺碘酮治疗慢性心力衰竭合并室性心律失常的有效性和安全性。方法回顾分析48例慢性心衰伴有症状的室性心律失常患者，常规抗心衰治疗病情稳定后，予以口服胺碘酮0．2g／次，每天3次，连用7d，后改为0．2g／次，每天2次，连用7d，后减为0．1～0．2g，每天1次维持，应用动态心电图、超声心动图等评价治疗室性心律失常效果、心功能变化、心率、QT间期变化和不良反应。结果48例胺碘酮治疗室性心律失常总有效率为93．8％，其中显效29例（60．4％），有效16例（33．3％），心功能提高1级者占83％，未出现严重不良反应。结论胺碘酮治疗心衰合并室性心律失常是有效和安全的。

Objective To observe the efficacy and safety of amiodarone in the treatment of chronic heart failure with ventricular arrhythmias. Methods 48 patients with chronic heart failure and VA were retrospectively analyzed. After the positive treatment against heart failure when the conditions were stable, amiodarone was taken orally 0. 2 g three times a day for a week,then which was taken 0.2 g two times a day for a week and finally which was taken 0. 1 -0.2 g one time a day. Before and After the treatment the improvement of VA, heart function, heart rate, change of QT internal and side - effect were observed. Results The total effective rate for VA was 93.8% , including obvious effective rate 60. 4% and effective rate 33.3%. The patients whose heart function was elevated by 1 grade accounted for 83%. No serious side - effects were showed in the treatment. Conclusion The administration of amiodarone for patients with heart failure complicated with VA is effective and safe.