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慢病毒载体介导RNAi的研究进展 被引量:4

Advance in RNAi Mediated with Lentivirus-based Vectors
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摘要 RNA i通过双链RNA的介导,特异性阻抑相关序列的表达,从而导致转录后水平的基因沉默。广泛存在于真菌、植物和动物等真核生物中。慢病毒载体是理想的真核细胞基因转移工具,被广泛应用于相关的RNA i研究领域,例如抗病毒研究、癌症及其治疗、遗传性疾病的治疗、基因治疗。现已发现,慢病毒载体能够介导组织特异、时间特异的RNA i,在疾病的基因靶向性治疗上必有广阔的前景。 RNA interference is a post-transcriptional gene silencing mechanism, by which double-stranded RNA specifically suppresses the expression of coherent sequences. Consequently, RNA interference can be observed in eukaryotic organisms including fun- gi,plants and animals. As a good eukaryotic cells gene transfer vector, lentivirus-based vectors are generally applied in RNAi-related research, such as antiviral research, research and therapy of cancer, therapy of hereditary diseases and gene therapy. RNAi mediated by lentivirus-based vectors is tissue-specific and time-specific, thus, it would be applied helpfully in targeted gene therapy.
出处 《生物技术通报》 CAS CSCD 北大核心 2009年第7期21-26,共6页 Biotechnology Bulletin
关键词 RNAI 慢病毒载体 基因治疗 RNA interference Lentivirus-based vectors Gene therapy
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  • 1Siong-Seng Liau M.B.Ch.B.,Stanley W. Ashley M.D.,Edward E. Whang M.D.. Lentivirus-mediated RNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma[J] 2006,Journal of Gastrointestinal Surgery(9):1254~1263

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