肝气郁结证患者血浆抗利尿激素的变化

Plasma antidiuretic hormone changes in patients with Ganqi stagnation *

目的研究肝气郁结证的病理生理基础，检验血浆抗利尿激素含量变化与肝气郁结证的相关性．方法用ＲＩＡ法测定辨证属于肝气郁结的神经衰弱、乳痛症、慢性胃炎和慢性胆囊炎患者血浆抗利尿激素含量．第一批测定３０例，第二批测定２８例，设健康对照组进行比较．结果两批患者血浆抗利尿激素含量分别为５２８ｎｇ／Ｌ±１９１ｎｇ／Ｌ和４８５ｎｇ／Ｌ±１６２ｎｇ／Ｌ显著高于健康人对照组的２９９ｎｇ／Ｌ±１０４ｎｇ／Ｌ和２８３ｎｇ／Ｌ±９８ｎｇ／Ｌ（ｔ＝５７９和４９４，Ｐ＜００１）．异病同证比较无显著性差异（Ｐ＞００５）．结论血浆抗利尿激素水平升高是肝气郁结证相关性较强的指标之一．肝气郁结证与中枢神经对精神情绪调节功能异常密切相关．

AIM To investigate the pathophysiological basis of Ganqi ( Liver qi ) stagnation and the relationship between plasma contents of antidiuretic hormone and the Ganqi stagnation. METHODS The plasma contents of antidiuretic hormone in 30 (first run) and 28 (second run) patients with Ganqi stagnation who were diagnosed as having neuroses, breast diseases, chronic gastritis and chronic cholecystitis were determined by radioimmunoasay compared with normal controls. RESULTS The plasma contents of antidiuretic hormone of the two runs were 52 8ng/L ± 19 1ng/L and 48 5ng/L ± 16 2ng/L , respectively, remarkably higher than that in the control group of 29 9ng/L ± 10 4ng/L and 28 3ng/L ± 9 8ng/L ( t =5 79, t =4 94, P <0 01). No significant difference was found in different diseases with the same syndromes. CONCLUSION The increase of antidiuretic hormone is a significant correlative index of Ganqi stagnation. Ganqi stagnation is closely related with the function of regulating emotion of the central nervous system.