硝唑尼特治疗犬贾第虫病的研究

The therapeutic effect of Nitazoxanide on the dogs infected with Giardia canis

选择试验犬8只,将其随机分为4个小组,每组2只。连续6 d对8只试验犬分别进行粪检,确定无贾第虫感染后,用体外纯培养的犬贾第虫滋养体接种试验犬,然后每天采集试验犬新鲜粪便40 g,用硫酸锌漂浮法进行粪检,当检测犬贾第虫感染呈阳性时,分别用1、24、mg/kg体质量剂量的硝唑尼特对1、2、3组试验犬进行灌服治疗,第4组试验犬不用药作为对照。用药后,每天以同样的方法检测贾第虫包囊,并计数。结果表明,以24、mg/kg体质量给药的试验犬1 d后粪检结果转为阴性,以1 mg/kg体质量给药的试验犬4 d后粪检结果转为阴性。结果表明以2、4 mg/kg体质量剂量的硝唑尼特对犬贾第虫病有很好的疗效。

To observe the therapeutic effect of Nitazoxanide（NTZ） on dogs infected with Giardia canis trophozoires. Eight dogs were infected with Giardia canis trophozoites and divided into four groups rondomly, GI： 2 dogs treated with Nitazoxanide at a single dose of 1 mg/kg body weight;G2：2 dogs treated with NTZ at a single dose of 2 mg/kg;G3：2 dogs treated with NTZ at a single dose of 41 mg/kg;G4：2 dogs treated without drugs as control. All groups were examined for Giardia canis cysts by Zinc Sulfate Flotation. Each group was subjected to collect stool per day and counted cysts. The results of G2 and G3 were negative after 1th day. G1 were negative after 4th days. The results indicated that NTZ at a dose of 2 mg/kg and 4 mg/kg in dogs had a faourable effect on the dogs infected with Giardia eanis.