子宫肌瘤患者血清、瘤组织中IGFBP-3的表达变化及意义

Change and significance of IGFBP-3 in serum and leiomyoma tissue of patients with uterine leiomyoma

目的观察子宫肌瘤患者血清及瘤组织中胰岛素样生长因子结合蛋白-3(IGFBP-3)的表达变化。方法采用ELISA法检测60例子宫肌瘤患者与60例正常妇女血清IGFBP-3,用免疫组化法检测上述60例子宫肌瘤患者子宫肌层和子宫肌瘤组织中的IGFBP-3。结果子宫肌瘤患者血清IGFBP-3水平低于正常妇女,IGFBP-3在子宫肌瘤组织中的表达较正常子宫肌层中的表达减低,P均<0.01。结论子宫肌瘤患者血清及瘤组织中IGFBP-3表达均降低,可能与子宫肌瘤的发生、发展有关。

Objective To detect the change of insulln-like growth factor binding protein-3 （IGFBP-3） in serum and leiomyoma tissue of patients with uterine leiomyoma. Methods The serum IGFBP-3 from 60 cases of uterine leiomyoma and 60 cases healthy women was tested by ELISA,the IGFBP-3 leiomyoma tissue and myometrium tissue from the 60 cases uterine leiomyoma was tested by immunohistochemistry. Results In patients with uterine leiomyoma, the serum IGFBP-3 was significantly lower than that in healthy women, the IGFBP-3 in leiomyoma tissue was significantly weaker than that of normal myometrium, P 〈0.01. Conclusion The IGFBP-3 in both serum and leiomyoma tissue are lower in patients with uterine leiomyoma, which suggests that IGFBP-3 play important role in the occurrence, development of uterine leiomyoma.