山海神茵汤治疗非酒精性脂肪肝58例疗效观察

Clinical Observation of Shan-hai Shen-yin Decoction on Nonalcoholic Fatty Liver,A Report of 58 Cases

目的:探讨山海神茵汤治疗非酒精性脂肪肝病的临床疗效。方法:选择非酒精性脂肪肝患者108例,按就诊顺序,随机分为治疗组58例和对照组50例。治疗组予自拟山海神茵汤治疗,每次口服200mL,2次/d;对照组予水林佳胶囊3粒/次,3次/d。疗程均为12周。结果:治疗组58例,治愈30例,显效23例,无效5例,总有效率91.38%;对照组58例,治愈22例,显效15例,无效13例,总有效率77.59%。两组比效差异具有显著性意义(P(0.05)。两组血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)治疗后均有所降低,与治疗前比较差异有显著性意义(P<0.01),说明两组方案均能有效改善肝功能;治疗组在改善血中甘油三酯(TG)、总胆固醇(TC)水平方面不优于对照组(P>0.05)。结论:自拟山海神茵汤可有效治疗非酒精性脂肪肝。

Objective： To observe the clinical curative effect of Shah-hal Shen-yin Decoction on nonalcoholic fatty liver disease. Method： 108 cases with nonalcoholic fatty liver disease were divided into two groups randomly according to visiting sequence. 58 cases in treatment group were treated by Shan- hal Shen - yin Decoction, 200ml once and two times a day. And 50 cases in control group were treated by Shui-lin-jia Capsule, 3 capsules once and 3 times a day. The treatment course included 12 weeks. Result： In treatment group 30 cases were cured, 23 cases were effective, and 5 cases were ineffective. The total effective rate was 91.37%. In control group 22 cases were cured, 15 cases were effective, and 13 cases were ineffective. The total effective rate was 74%. There was significant difference between the two groups （ P 〈 0.05 ）. ALT and AST were decreased after treating, and there was also significant difference between before treating and after treating （P 〈0. 01 ）. That was to say, the two projects could improve hepatic function, but treatment group was not better than control group on improving TG and TC （ P 〉 0. 05 ）. Conclusion ： Shan-hai Shen-yin Decoction can heal nonalcoholic fatty liver disease effectively.