补阳还五汤溶度峰及介电需量的研究

Solubility peak and dielectric requirement of Buyang Huanwu docoction

目的：测定补阳还五汤全方的溶度峰及介电需量，为中药复方提取溶媒的选择提供理论与实验依据。方法：分别以溶度参数14．11～47．86，介电常数1～80的11种溶媒体系，在接近药材临界饱和溶媒体积％，于25℃下浸提补阳还五汤粗粉，按《中国药典》2005年版附录浸膏得率测定项下测定表观溶解度。结果：各溶媒体系浸渍药材所需的临界饱和体积K，分别为0．210，0．310，0．490，0．360，0．770，0．930，0．860，0．920，1．080，1．000，1．140mL·g^-1；各溶媒体系最大表观溶解度分别为114．0，101．3，73．4，109．4，210．7，295．0，501．4，437．0，355．6，423．1，210．6g·L^-1，从而得出补阳还五汤粗粉以甲醇-水（68：32）浸渍时，其表观溶解度最大，出现溶度峰。对应的介电需量约为47．5。结论：中药及复方表观溶解度的大小决定于所提溶媒的介电常数；并有稳定的介电需量与之对应。

Objective： To study the solubility peak and dielectric requirement of the Buyang Huanwu docoction materials, and provide theoretical and experimental foundation for selecting extraction solvent for extracting traditional Chinese drugs （TCD）. Method： 11 types of solvents were employed as single or complex solvent systems, whose solubility parameter and dielectric constant were from 14. 11 to 47. 86, dielectric requirement from 1 to 80 respectively, to lixiviate Buyang Huanwu decoction （5 g per samples） in nearly saturate volume as Vo for materials at 25℃. The apparent solubilities of extracts were determined and calculated out according to the section of determination of extract in the appendix of ＇ Chinese Pharmacopoeia＇. Result： The saturate solvent Vo for materials powder were 0. 21,0. 31,0. 49, 0. 36, 0. 77, 0. 93, 0. 86, 0. 92, 1.08, 1.00, 1.14 mL·g^-1, respectively. The apparent solubility of Buyang Huanwu decoction for each solvent system were 114. 0, 101.3, 73.40, 109.4, 210. 7, 295.0, 501.4, 437. O, 355.6, 423. 1, 210. 6 mL·g^-1, respectively, among which the max apparent solubility, illustrated as solubility peak, was carried out by methanol-water （68：32 ） with 47. 5 corresponding to the Buyang Huanwu docection dielectric requirement. Conclusion： The apparent solubilities of （TCD） and their formula are controlled by dielectric constant of extraction solvent, and are in accordance with stable dielectric requirement.