摘要
为探讨补肾中药治疗更年期妇女骨质疏松症的临床疗效,本研究对47例确诊为骨质疏松症的更年期妇女随机分为治疗组和对照组,分别给服补肾益骨膏(熟地、淫羊藿、紫河车、泽泻、龙骨等组成)和安慰剂。在治疗前后进行桡骨、尺骨骨密度,骨代谢生物化学指标和雌二醇测定及肾虚证候评分。结果显示:3个月后,治疗组桡骨、尺骨骨矿含量均较治疗前增加(均P<0.01),而对照组呈现进行性下降,两者比较有显著性差异(P<0.01);治疗组血清骨钙素水平较治疗前升高(P<0.01),组间对照无显著性差异;而两组的血清碱性磷酸酶、尿钙治疗前后均无显著性改变(P>0.05);治疗组雌二醇维持于治疗前水平,略有上升,差异无显著意义(P>0.05),而对照组则进行性下降;治疗组肾虚证候评分在治疗后减低(P<0.05)。认为补肾益骨膏能够防治更年期妇女的骨质丢失。
o explore the effect of Bushen Yigu Gao (BYG) on postmenopausal osteoporosis (PMO),47 women with PMO were randomly allocated to two groups. Group I was treated with BYG orally while Group Ⅱ with placebo as control. The bone mineral density of radius and ulna, biochemical paramenters of bone metabolism, serum estradiol and the scores of kidney_deficiency were determined before and after treatment. The results showed that: after a treatment course of 3 months, the bone mineral contents in radius and ulna increased in Group I while decreased in control group, the differences being significant(P<0.01);in Group I, the level of serum bone gla protein increased (P<0.01), while the concentrations of ALP and urinary calcium changed without significant differences(P>0.05); the level of E2 increased slightly in group I and decreased in control group, but the difference was not significant(P>0.05); the scores of kidney_deficiency in Group I decreased obviously (P<0.05). It is suggested that BYG can inhabit the loss of bone mineral in menopausal women and exert a certain effect on PMO.
出处
《广州中医药大学学报》
CAS
1998年第2期84-87,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家中医药管理局重点课题
关键词
骨质疏松
绝经后
补肾益骨膏
中医药疗法
OSTEOPOROSIS, POSTMENOPAUSAL/TCD ther.
@ BUSHEN YIGU Gao/pharmacology
REINFORCING KIDNEY SU EMISSION
BONE DENSITY/drug eff.
OSTEOCALCLN/blood
ALKALINE PHOSPHATASE/blood
ESTRADIOL/blood
CALCIUM/urine