皮肤瘢痕癌变组织中Cx43、Survivin表达的相关性

Correlation between Cx43 and survivin expression in skin scar carcinoma

目的探讨皮肤瘢痕和皮肤瘢痕癌与Cx43、Survivin蛋白表达的关系。方法用SP法免疫组化对10例皮肤瘢痕癌组织、10例皮肤瘢痕组织、10例正常皮肤组织的石蜡包埋标本的Cx43、Survivin进行检测。利用图像分析系统采集、分析图像,并对数据进行统计学处理。结果Cx43在皮肤瘢痕癌、皮肤瘢痕、正常皮肤组织中表达逐渐降低,两两比较均有统计学意义(P<0.05)。Survivin在皮肤瘢痕癌、皮肤瘢痕组织中的表达明显高于正常皮肤组织(P<0.01),而在皮肤瘢痕癌组织、皮肤瘢痕组织中的表达无统计学意义(P>0.05)。相关性分析显示,Survivin与Cx43蛋白在皮肤瘢痕癌中的表达呈负相关(P<0.05)。结论Cx43、Survivin在皮肤瘢痕和瘢痕癌组织中的异常表达,可能共同促进了皮肤瘢痕癌变的发生和发展。

Purpose To study the relation between Cx43 and survivin protein expression in skin scar and skin scar carcinoma. Methods The expression of Cx43 and survivin in 10 skin scar carcinoma tissues, 10 skin scar tissues and 10 normal skin tissues was detected by the immunohistochemical SP method. Pictures were collected and analyzed by computerized image-analysis,and statistical analysis was conducted with SPSSsoflware. Results The expression of Cx43 in skin scar carcinoma and skin scar tissues and normal skin tissues was lowered gradually. Each of two groups was statistically different （P 〈 0. 05）. The expression of survivin in skin scar carcinoma and skin scar tissues was significantly higher than normal skin tissues （P 〈0.01 ）. However, no statistic differences of it were measured between skin scar carcinoma and skin scar tissues（P 〉 0. 05 ）. Correlated analysis showed that it was inversely correlated that the expression of survivin and Cx43 protein in skin scar carcinoma tissues. Conclusions The low expression Cx43 proteins and the high expression of survivin may be involved in the process of the development or progression of skin scar carcinoma.