嵊州刺果毛茛的化学成分研究

Studies on the Chemical Constituents in Ranunculus muricatus L.

目的对嵊州刺果毛茛的化学成分进行分离和结构鉴定。方法采用溶剂提取和各种色谱法分离得到8个化合物,运用多种波谱技术鉴定其化学结构。结果8个化合物分别鉴定为豆甾-4-烯-3,6-二酮(I)、豆甾醇(II)、白头翁素(Ⅲ)、七叶内酯二甲醚(IV)、β-谷甾醇(V)、原儿茶醛(VI)、原儿茶酸(Ⅶ)和木犀草素(Ⅷ)。结论化合物I,Ⅳ,V,Ⅵ为首次从刺果毛茛中分离得到。

OBJECTIVE To isolate and determine the chemical constituents from Shengzhou Ranunculus muricatu L.. METHODS Eight compounds were isolated and purified by extraction and different kinds of column chromatography. The structures were determined on the basis of extensive spectral analysis such as EI-MS, ^1H-NMR, ^13C-NMR and DEPT. RESULTS The structures were elucidated as stigmasta-4-ene-3, 6-dione（Ⅰ）, stigmasterol（Ⅱ ）, anemonin （Ⅲ）, scoparone （Ⅳ）, β-sitosterol（Ⅴ）, protocatechuic aldehyde （Ⅵ）, protocatechuic acid（Ⅶ） and l uteolin （Ⅷ）, respectively. CONCLUSION Compounds（ Ⅰ, Ⅳ,Ⅴ, Ⅵ） were isolated from Ranunculus muricatus for the first time.