抗抑郁剂治疗幽门螺杆菌阳性的慢性胃炎的临床对照分析

The Therapeutic Effect of Anti-depressants on Chronic Gastritis with Helicobacter pylori

目的探讨抗抑郁剂对幽门螺杆菌阳性的慢性胃炎的治疗作用。方法将56例幽门螺杆菌阳性的慢性胃炎分成A、B两组,A组30例予三联治疗,B组26例予抗抑郁剂(米氮平或帕罗西汀)治疗,对A、B两组治疗前与治疗6周时汉密顿抑郁量表(HAMD)总分、不良反应量表(TESS)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)浓度及治疗6周后幽门螺杆菌的未愈率进行测定、对照。结果两组治疗后HAMD总分、TESS、IL-6、TNF-α均提示差异有显著性,而幽门螺杆菌阳性的慢性胃炎的幽门螺杆菌未愈率两组比较差异无显著性。结论抗抑郁剂可能是通过改变患者的免疫功能而抑制幽门螺杆菌的生存,可以作为幽门螺杆菌阳性的慢性胃炎有效治疗途径之一。

OBJECTIVE To estimate the therapeutic effect of anti-depressants （mirtazapine or Paxil）in the treatment of the chronic gastritis with Helicobacter pylori. METHODS Fifty-six patients who were suffering from the chronic gastritis with Helicobacter pylori were divided into group A （30 cases） and group B （26 cases）. Patients in group A took the triple treatment, and patients in group B took anti-depressants （mirtazapine or Paxil）. Score of HAMD and TESS, blood concentration of IL-6 and TNF-α of each patient before and after 6 weeks＇ treatment, and the uncured ratio of Helicobacter pylori were measured and compared respectively. RESULTS The score of HAMD and TESS, blood concentration of IL-6 and TNF-α of each patient in the two groups changed significantly （P 〈0.01）, while the uncured ratio of Helicobacter pylori showed no differences between the two groups. CONCLUSION Anti-depressants might inhibit the growth of Helicobacter pylori by improving the immunity function of the patients, and it might be a effective way to cure the chronic gastritis with Helicobacterpylori in future.