用于评价便携式血气胸引流装置的动物模型的建立

Development of an animal model used for the evaluation of the portable hematopneumothorax draining device

目的建立并探讨一种可评价便携式血气胸引流装置引流效果的实验动物模型。方法将18只实验犬平均分为3组：单纯血胸模型组、单纯气胸模型组和持续出血型血气胸模型组，建立动物模型后，行X线胸片或B超检查，监测建模前、建模后10、30、60min实验犬呼吸频率、心率和末梢脉氧饱和度的变化。结果经X线胸片或B超证实，3组实验犬建模后10min呼吸和心率均明显升高，脉氧饱和度下降，但单纯血胸组和单纯气胸组呼吸频率、脉氧饱和度在建模后10、30、60min3个时间点上比较差异无统计学意义（P〉0．05），心率在建模后30min和60min2个时间点上比较差异无统计学意义（P〉0．05），持续出血型血气胸组实验犬建模后30min呼吸和心率开始下降，脉氧饱和度急剧下降。结论该血气胸动物模型适用于评价便携式血气胸引流装置。

Objective To investigate an animal model used for the evaluation of the efficiency of the portable hematopneumothorax draining device. Methods Eighteen dogs were equally divided into three groups, i.e. the pure hemathorax group, the pure pneumothorax group, and the prolonged hematopneumothorax group. Following development of the animal model, Chest X-ray film and uhrasonography were implemented to measure the respiratory frequency, heart rate and change pattern of oxygen saturation in peripheries of the experimental animals, pre-experiment, 10 min, 30 min and 60 min after the development of the model. Results Chest X-ray and uhrasonography revealed that respiratory frequency, heart rate of the three animal groups elevated significantly, while oxygen saturation dropped markedly 10 minutes after the development of the model. However, for the pure hemathorax and pneumothorax groups, no significant differences were noted in the respiratory frequency and oxygen saturation at 10 min, 30 min and 60 min after the development of the model. And there were no differences in heart rate, which increased again 30 min after the development of the model, when comparisons were made between the two time points of 30 min and 60 min. Respiratory frequency and heart rate for the prolonged hematopneumothorax group began to decrease and oxygen saturation dropped sharply, 30 rain after the development of the model. Conclusions This animal model is suitable for the evaluation of the efficiency of the portable hematopneumothorax draining device used in the animal experiments.