多叶姜黄(Curcuma comosa Roxb.)的化学成分

Chemical constituents of rhizome of Curcuma comosa Roxb.

目的对泰国产姜科姜黄属植物多叶姜黄（Curcuma comosa Roxb．）干燥根茎甲醇提取物的化学成分进行分离和结构鉴定。方法C.comosa Roxb．的甲醇提取物经乙酸乙酯-正丁醇-水依次萃取后，对各萃取部分采用正一反相硅胶柱色谱和制备型HPLC进行分离，经理化常数测定、核磁共振技术分析等方法鉴定了化合物的结构。结果分离得到8个化合物，分别被鉴定为异蓬莪术环二烯酮（isofuranodienone，1），蓬莪术环二烯酮（furanodienone，2），1（10）Z，4Z-蓬莪术二烯-6-酮[1（10）Z，4Z-furanodiene-6-one，3]，泽泻醇（alismol，4），2，2，6-三甲基-1-氧螺[2，5]辛-5-烯-4-醇（2，2，6-trimethyl-1-oxaspiro[2，5]oct-5-en-4-ol，5），卜羟基-α，α，4-三甲基-3-环己烯-1-甲醇（1-hydroxy-α，α，4-trimethyl-3-cyclohexene-1-methanol，6），6-羟基-3（卜羟基-1-甲基乙基）-6-甲基-2-环己烯-1-酮（6-hydroxy-3（1-hydroxy-1-methylethyl）-6-methyl-2-cyclohexen—1—one，7），（1S，2S，4R）-1，8桉叶素-2—O-β-D-葡萄糖苷（（1S，2S，4R）-2-hydroxy-1，8-cineole β-D-glucopyranoside，8）。结论化合物3—8为首次从该属植物中分离得到。

Objective To isolate and identify chemical constituents from rhizome of Curcuma comosa Roxb. cultivated in Thailand. Methods Methanol extract of C. comosa Roxb. was suspended in water and partitioned successively by ethyl acetate, n-butanol. Ethyl acetate and n-butanol extracts were subjected to silica gel, ODS, and HPLC. Physicochemical characters and spectral analysis were employed to identify structures of isolated compounds. Results Eight compounds were isolated and identified as isofuranodienone （ 1 ）, furanodienone （ 2 ）, 1 （ 10 ） Z,4Z-furanodiene-6 -one （ 3 ）, alismol （ 4 ）, 2,2,6 -trimethyl- 1 -oxaspiro [ 2,5 ] oct-5-en-4- ol （ 5 ）, 1 -hydroxy-α, α, 4 -trimethyl-3-cyclohexene- 1 -methanol （ 6 ）, 6-hydroxy-3 （ 1-hydroxy- 1 -methylethyl ） -6-methyl-2-cyclohexen-1 -one （ 7 ）, （ 1 S, 2S, 4R ） -2-hydroxy-1,8-cineole β-D-glucopyranoside （ 8 ）. Conclusion Compounds 3-8 are obtained from the genus of Curcuma for the first time.