三维适形放疗联合卡培他滨治疗局部晚期胰腺癌

Treatment of local advanced pancreatic carcinoma with three dimensional conformal radiotherapy combined with capecitabine

目的评价三维适形放疗联合卡培他滨治疗局部晚期胰腺癌的疗效。方法47例胰腺癌患者分为卡培他滨+三维适形放疗(综合组,25例)和单纯三维适形放疗(单放组,22例),比较疼痛缓解率、近期疗效及生存率。结果综合组和单放组疼痛缓解率分别为80%和65%,近期有效率分别为76%和59%。综合组1、2年生存率分别为64%、16%,显著高于单放组的45.5%、9.1%(P<0.05)。主要毒副反应为1～2级消化道反应及1～3级血液毒性。结论三维适形放疗联合卡培他滨治疗局部晚期胰腺癌,副反应较轻,能改善患者的生存质量,延长生存期。

Objective To evaluate therapeutic effect of three-dimensional eonformal radiotherapy （3DCRT） combined with capecitabine on the local advanced pancreatic carcinoma. Methods Foutty-seven patients with pancreatic carcinoma were divided into group A treated with capeeitabine combined with 3DCRT in 25 cases and group B treated with 3DCRT alone in 22 eases. Pain remission rate, short term efficiency and survival rate were compared between two groups. Results Pain remission rate was 80% for group A and 65% for group B. Short term effective rate was 76% for group A and 59% for group B. The 1- and 2-year survival rates were 64% and 16% in group A,whieh were significantly higher than 45.5% and 9.1% in group B （P〈0.05）. Main toxic and side effects were digestive tract reaction （ Ⅰ - Ⅱ grade） and blood toxicity （ Ⅰ - Ⅲ grade）. Conclusion Treatment of local advanced pancreatic carcinoma with 3DCRT combined with capeeitabine can improve the life quality and prolong the survival rate with slight side effects.