妊娠高血压综合征患者vWF的测定

Examination of vWF in pregnancy-induced hypertension syndrome

目的探讨血管性假性血友病因子(vWF)与妊娠期高血压综合征(PIHS)的相关性。方法用ELISA法测定下列各组患者血清vWF浓度:子痫前期组(A组)患者25例(轻度11例,A1组;重度14例,A2组);妊娠期高血压组(B组)患者15例;正常孕妇晚孕组(C组)15例;另取正常育龄非妊娠妇女15例为对照组(D组)。结果A组vWF浓度为(2.11±0.37)ng/ml,明显高于B组的(1.76±0.30)ng/ml,C组的(1.51±0.56)ng/ml和D组的(0.99±0.25)ng/ml(P<0.05)。A2组vWF浓度为(2.31+0.42)ng/ml,明显高于A1组的(1.85±0.25)ng/ml(P<0.05)。C组vWF浓度明显高于D组(P<0.05)。结论血浆vWF浓度随PIHS和子痫的严重程度而升高,可以作为内皮细胞功能受损的一项指标。

Objective To study the relationship of serum yon Willebrand factor（vWF） and pregnancy-induced hypertension syndrome （PIHS）. Methods With ELISA,the serum concentrations of vWF were examined and compared in 25 PIHS patients with preeclampsia （group A）, who were subdivided into mild preeclampsia （group A1,11 cases）） and severe preeelampsia （A2, 14 cases）, 15 cases with gestational hypertension（group B）, 15 cases with third trimester （group C）, and 15 nonpregnancy women as the controls（group D）. Results The serum vWF of group A was （2. 11 ± 0.37） ng/ml,which was significantly higher than that of group B[（1.76± 0.30）ng/ml], group C [（1.51±0.56）ng/ml],or group D [（0.99±0. 25）ng/ml ]（P〈0.05）. The serum vWF of group C was significantly higher than that of group D [（1.76±0.30） ng/ml] （P〈0.05） . The serum level of vWF of group A2 was significantly higher than that of group A1 E（2.31±0.42） ng/ml vs. （1.85± 0. 25）ng/ml]（P〈0.05）. Conclusion The serum levels of vWF increase with severity of HIHS and preeclampsia. Serum vWF can be taken as a marker of endothelial damage.