高危型人乳头瘤病毒测定与宫颈癌及其癌前病变的关系

Relationship of high risk human papilloma virus and cervical cancer and precancer

目的探讨高危型人乳头瘤病毒(HR-HPV)测定与宫颈癌及其癌前病变的关系。方法选择首次诊断为宫颈癌及其癌前病变患者387例,在治疗前用第二代杂交捕获法(HC-Ⅱ)进行HR-HPV的测定,以病理学结果为确诊及分组标准,探讨HR-HPV阳性率、载量与宫颈病变之间的关系。结果HR-HPV阳性337例,阳性率为87.08%,阳性时病毒载量范围1.00～3221.87pg/ml。其中,低级别病变阳性率为75.41%,高级别病变阳性率为92.16%,宫颈癌的阳性率为100%。结论随着宫颈病变严重程度的增加,HR-HPV的检出率随之增加;但病毒载量与宫颈病变的严重程度无明显关系。

Objective To explore the relationship of high risk human papilloma virus （HR- HPV） and cervical cancer and cervical intraepithelial neoplasia （CIN）. Methods A total of 387 patients received HR-HPV test before the treatment for CIN and cervical cancer. The load of HR- HPV was determined by hybrid capture Ⅱ （HC- Ⅱ ） method. Diagnosing and grouping were based on the results of histopathology. Results Of 387 cases,337 cases（87.08%） were HR-HPV positive with a virus load of 1.00-3221.87 pg/ml. The positive rate of HPV DNA was 92.16% for HSIL, 75.41% for LSIL and 100% for cervical cancer. Conclusion The higher the cervical lesion stage, the higher positive rate of HPV DNA. There is no significant association between viral load of HPV DNA and cervical lesion.