戊乙奎醚在严重感染与感染性休克患者中的应用

Clinical application of penehyclidine hydrochloride in patients with severe sepsis and septic shock

目的探讨戊乙奎醚对严重感染与感染性休克患者的治疗作用。方法符合严重感染与感染性休克诊断标准的ICU住院患者58例,随机分为两组,每组29例。除常规抗休克治疗外,A组另外肌注戊乙奎醚,首剂4～6mg,然后每8h重复给予2mg维持;B组另外静注654-2,首剂10～20mg,然后每15～30min重复同量维持。动态监测给药前后血流动力学、组织灌注指标及细胞因子变化。结果两组微循环均有明显改善。A组给药次数少,不增加心率。结论戊乙奎醚和654-2皆可明显改善严重感染与感染性休克患者微循环。戊乙奎醚给药次数少,使用方便,不增加心率,优于654-2。

Objective To observe the outcome of penehyclidine hydrochloride （PH） in the treatment of severe sepsis and septic shock. Methods Fifty-eight patients were randomly divided into two groups with 29 cases each. On the base of antishok therapy, the patients in group A were given intramuscular injection of PH in an initial dose of 4-6 mg and 2 mg once per 8 h thenafter, those in group B were given intravenous injection of 654-2 in an initial dose of 10-20 rag,which was repeated every 15 - 30 min. The changes of hemodynamics, indexes of tissue perfusion and cytokines were examined during therapy. Results The microcirculation was improved significantly in both groups after PH or 654-2 administration. HR was less in group A than that in group 13. Conclusion Both PH and 654-2 are effective in treating severe sepsis and septic shock. PH is better in keeping HR stable than 654-2.