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非放射性标记物BrdU研究进展 被引量:4

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摘要 溴脱氧尿嘧啶核苷(bromodeoxyuridine,BrdU)是 DNA前体胸腺嘧啶核苷类似物,通过竞争掺入S期细胞单链DNA核苷酸序列替代胸腺嘧啶。BrdU与胸腺嘧啶竞争掺入的强度可能与细胞增殖异常有关,如肝癌细胞约11.6%的胸腺嘧啶被替代,而正常肝细胞仅有1.l%。既往在分子遗传学等研究中常采用同位素标记,但有放射污染。
作者 李新明
出处 《口腔材料器械杂志》 1998年第1期32-35,共4页 Chinese Journal of Dental Materials and Devices
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