C-反应蛋白及其-717A／G多态性与心房颤动的相关性

Relationship between C-Reactive Protein and Atrial Fibrillation

目的:研究江苏南通地区人群高敏C-反应蛋白(hs-CRP)浓度及其-717A/G多态性与心房颤动的相关性。方法:通过对92例心房颤动患者和60例非房颤对照者的性别、年龄、体质量指数等一般临床资料的比较,分析房颤与其危险因素的关系。应用免疫比浊法测hs-CRP,PCR-RFLP法检测CRP-717A/G基因型。结果:房颤患者CRP浓度与左房内径(LAD)呈正相关(r=0.58,P<0.01),房颤组CRP浓度显著高于对照组(P<0.01),非阵发性房颤患者hs-CRP浓度高于阵发性房颤患者(P<0.05)。2组间A/A与G/A+G/G基因型分布差异无统计学意义(P>0.05),但G等位基因在房颤组中表现为低频率(P<0.05)。结论:hs-CRP浓度与房颤及房颤亚型相关,hs-CRP浓度与LAD呈正相关,炎症有可能通过结构重构来影响房颤的发生,CRP-717A/G多态性与房颤的关系尚需更大规模的前瞻性研究。

Objective： To investigate the relationship between C-reactive protein （CRP） and its -717A/G polymorphism in atrial fibrillation （AF） of the population of the city of Nantong. Methods： The relationships between AF and AF risk factors were analyzed by comparing genders, ages and body mass index （BWI） in 92 AF patients and 60 non-AF control subjects. The serum CRP levels were detected by immunoturbidimetry in of the two groups. The CRP-717A/G polymorphism was detected by polymerase chain reaction-restriction fragment-length polymorphism in patients and control subjects. Results： The serum CRP level was positively correlated with the left atrium internal diameter （LAD） in AF patient group（r = 0.58, P 〈 0.01）. The level of CRP was significantly higher in AF patient group compared with that of control group （P 〈 0.01）. The serum CRP level was higher in patients with non-paroxysmal atrial fibrillation than that of patients with paroxysmal atrial fibrillation （P 〈 0.05）. There was no significant difference in the frequency of CRP genotype between AF and control groups （P 〉 0.05）. But the alleles frequency of the G was lower in AF group than that of control group（P〈 0.05）. Conclusion： The serum CRP level is associated with AF and its subgroups. The serum CRP level is positively correlated with LAD. The results suggest that the inflammation influences the AF though atrium reconstruction. The relationship between CRP -717A/G and AF still needs further large-scale perspective studies.