短暂性脑缺血发作患者血浆Hcy、ET、NO、FA、VitB_(12)水平变化的临床研究

Clinical study of plasma Homocysteineand、Endothelin、Mononitrogen Monoxide、Folic Acid and VitamineB_(12) in transient ischemic attack

目的探讨短暂性脑缺血(TIA)患者血浆同型半胱氨酸(Hcy)、内皮素(ET)、一氧化氮(NO)、叶酸(FA)、维生素B12(VitB12)变化及临床意义。方法检测60例暂性脑缺血患者血浆中同型半胱氨酸、内皮素(ET)、一氧化氮(NO)、叶酸、维生素B水平,并与同期42例健康体检者进行了对照。结果短暂性脑缺血组血浆Hcy、ET显著高于对照组,且差别具有显著性(P<0.01);NO、FA、VitB12的水平低于对照组(P<0.01)。短暂性脑缺血患者中高血压患者Hcy高于血压正常患者。结论短暂性脑缺血患者血浆Hcy、ET浓度升高,检测血浆Hcy含量变化对于患者病情观察、预后判断具有重要意义,短暂性脑缺血患者服用FA和VitB12等制剂对于治疗和预防具有重要临床价值。

Objective To detect the fluctuations and correlations of Homocysteineand, Endothelin, Mononitrogen Mouoxide,Folic Acid and VitamineB12 in the plasma of patients suffered from transient ischemic attack and to investigate the possible clinical signification of the changes. Methods 60 blood specimens form transient ischemie attack patients and 42 specimens from healthy individuals served as control group were obtained in this study and series of items of Homocysteineand,Endothelin,Mononitrogen Monoxide,Folic Acid and VitamineB12 were detected. Results The Homocysteineand and Endothelin values were increased in cerebral infarction group compared with that in control group and the difference were significant P 〈 0.01 ,while values of Mononitrogen Monoxide、Folic Acid and VitamineB12 were decreased compared with control group and the difference were significant （ P 〈 0.01 ）. Conclusion The Values of Homocysteineand and Endothelin were increased in acute cerebral infarction patients and surveillance of plasma Homoeysteineand. Endothelin. Mononitrogen Monoxide.Folic Acid and VitamineB12 values is essential to the observation of the state of illness and prognosis, especially the guidence of clinical medication of prescription ,of Folic Acid and VitamineB12 to acute cerebral transient ischemic attack.