以慢性腹泻为首发症状的胸腺瘤的探讨

Thymoma with the first symptom of chronic diarrhea

目的探讨胸腺瘤合并慢性腹泻,两者之间的关系及可能的发生机制。方法对8 9例胸腺瘤的临床资料进行回顾性分析。结果8 9例中有7例出现慢性腹泻(7.9%),原因多不明。7例中有4例自身抗体阳性。胸腺瘤切除后有5例腹泻症状明显缓解。结论胸腺瘤合并慢性腹泻,两者之间有一定的关系。推测自身免疫紊乱是此类腹泻的主要原因之一。对于不明原因的顽固性腹泻,应警惕胸腺瘤的可能。

Objective To investigate thymoma with chronic diarrhea, the relationship between them and the possible mechanism. Methods The medical records of all 89 patients diagnosed as thymoma were analyzed retrospectively. Results 7 of 8 9 patients （7/89） showed noteable chronic diarrhea, the cause of most diarrhea were unclear. 4 of 7 patients with chronic diarrhea showed positive tests for various autoantibodies. The symptom of 5 cases of chronic diarrhea were almost relieved after thymomas were resected. Conclusion Thymoma with chronic diarrhea, there is some relationship between them. The autoimmunity derangement should be considered the main cause of diarrhea in the group of patiens. To intractable chronic diarrbea with unclear cause should vigilance a possibility of thymoma. The possibility of thymoma should be of vigilance in irtractable chronic diarrhea of unclear cause.