口服避孕药对年轻女性乳腺密度的影响

Impact of oral contraceptives on mammographic breast density.

目的初步评价口服避孕药短期服用对年轻女性乳腺的影响。方法采用随机对照临床研究方法,数字化钼靶检查测定乳腺密度,实验组受试者口服避孕药12周(n=34),分别测定服药前及服药后的乳腺密度:对照组受试者予口服安慰剂12周(n=38),亦于相同时段行钼靶检查测定乳腺密度。比较二者乳腺密度的变化规律。结果实验组女性乳腺密度较服药前有增加的趋势(9.9±3.3vs10.5±3.2),但无统计学意义(P=0.17);而对照组受试者实验前后乳腺密度无明显变化(9.8±3.0vs9.9±2.9,P=0.43)。服用口服避孕药12周后的妇女乳腺的平均密度较服用安慰药的妇女乳腺平均密度大,但无统计学意义(10.5±3.2vs9.9±2.9,P=0.38)。结论短期服用口服避孕药不会明显增加年轻育龄妇女的乳腺密度。

Objective To evaluate impact of short-term oral contraceptives caplendus on mammographic breast density. Method An open, randomized, comparative trial was designed. Women were randomly assigned to receive treatment for 12 weeks with oral contraceptive containing 0.15 mg levonorgestrel ＋0.03mg ethinylestradiol in experimental group （n=34） or placebo in control group. Mammographic density which was expressed as volumetric breast density estimations was determined at baseline and after 12 weeks by an automated technique in full-field digital mammograms. Results There was slight increase of volumetric breast density in experiment group （9.9±3.3 vs 10.5±3.2, P=0.17） , whereas those allocated to placebo treatment only showed minor changes （9.8±3.0 vs 9.9±2.9,P = 0.43）. The mean breast density in experimental group was also higher than that in control group after treating for 12 weeks （10.5±3.2 vs 9.9±2. 9, P=0.38）. Conclusion Our findings demonstrated short-term oral contraceptives caplendus would not significant increase mammographic breast density of women in reproductive age.