重庆市01群霍乱菌株耐药性研究

Analysis On Antibiotic Resistance Of Vibrio Cholerae O1 Strains In Chongqing

目的了解1984～2005年重庆市01群霍乱弧菌的耐药性和耐药性的变迁。方法采用K—B法检测72株01群霍乱弧菌(小川型26株,稻叶型46株)对16种抗菌药物的敏感性。结果重庆地区01群霍乱弧菌对复方新诺明耐药、痢特灵和链霉素的耐药严重,耐药率分别为20.83%(15/72)、56.94%(41/72)和30.56%(22/72),小川型和稻叶型的耐药性不同。人群分离株对丁胺卡那、庆大霉素、妥布霉素、氨苄西林、新霉素和强力霉素敏感,未发现耐药菌株。但05年分离的两株环境分离株具有较高的耐药性。结论未发现重庆市01群霍乱弧菌人群分离株的耐药性有明显改变,但与一些地区报道的耐药性有明显的不同,这种地区差别和重庆市01群不同血清型的耐药性的差别有待于进一步研究。

Objective To study the antibiotic resistance ofVibrio cholerae Ol strains in Chongqing from 1984 to 2005. Methods Susceptibility to 16 antimicrobial agents was tested by K-B method in 72 isolates（26 Inaba strains, 46 Ogawa strains）. Results The drug resistance rate to Sulphamethoxazole/trimethoprim, Furazolidone and Streptomycin was 20.83%（15/72）, 56.94%（41/72） and 30.56%（22/72）, and the antibiotic resistance was different between the serotype Inaba strains and Ogawa strains. All clinical strains showed sensitivity to Amikacin, Gentamicin, Tobramycin, Ampicillin, Neomycin and Doxycycline hydrochloride. But the high drug resistance rate was founded in 2 isolated environment strains in 2005. Conclusion The drug resistance change has not founded in Vibrio cholerae Ol clinical strains in Chongqing form 1984 to 2005.But the results of drug resistance in Chongqing was quit different from some other region reports, the drug resistance difference in different region and different serotype of Vibrio cholerae 01 strains are need further to study.