急性肝炎、肝硬化血清—氧化氮和肿瘤坏死因子的研究

Study on the Nitric Oxide and Tumor Necrosis Factor in Serum of Patients with Accute Hepatitis and Liver Cirrhosis

为探讨急性肝炎、肝硬化中ＮＯ和ＴＮＦ变化的意义，测定了２５例急性肝炎和３５例肝硬化病人与３０例正常人血清中的ＮＯ和ＴＮＦα水平。结果显示：与正常人比较，急性肝炎患者血清ＮＯ水平无明显增高（Ｐ＞００５）；而ＴＮＦα水平明显增高（Ｐ＜００１），但较肝硬化为低（Ｐ＜００１）。肝硬化患者，ＮＯ和ＴＮＦα均显著增高（Ｐ＜００１）。提示：尽管ＮＯ不参予急性肝炎患者的肝细胞损伤，但ＮＯ和ＴＮＦα却能加剧肝硬化患者的病理生理学紊乱。

To study the significance of nitric oxide(NO) and tumor necrosis factor (TNF) in serum of patients with acute hepatitis and liver cirrhosis,the levels of NO and TNF in serum were measured in 25 patients with acute hepatitis,35 cirrhotic patients and 30 normal controls.The results showed that NO level in acute hepatitis was similar to that of normal controls(P>0 05),but its TNF α level was significantly higher than that of normal controls.Both the levels of NO and TNFα in serum of cirrhotic patients were significantly higher than that of mormal control and acute hepatitis.These results suggest that NO does not damage the hepatocytes of the patients with hepatitis,but the TNF and NO can increase the disorder of pathophysiology of the patients with liver cirrhosis.