摘要
为探索青蒿琥酯治疗恶性疟的最佳剂量和疗程,本研究在中国海南岛抗性恶性疟流行地区,采用青蒿琥酯片5d疗程总量600mg和7d疗程总量800mg治疗无并发症恶性疟疾,进行开放性随机比较。每组治疗50例,全部病例住院28d观察原虫复燃情况。结果:两组病例临床症状均被迅速控制。5d疗程组和7d疗程组退热时间分别为(24.0±13.6)h和(20.0±10.1)h,原虫转阴时间分别为(61.7±21.1)h和(55.8±15.8)h,两组无显著性差异。28d内原虫复燃率7d组为4.2%(2/48),5d组为19.1%(9/47),治愈率分别为95.8%和80.9%。两组比较有非常显著性差异(χ2=5.21,P<0.01),表明7d疗程可使复燃率明显下降。两组皆未见临床不良反应。提示青蒿琥酯7d疗程总量800mg是一个高治愈率的给药方案,可作为标准疗程剂量。
n open randomized comparative study of artesunate 600mg as a total dose for 5_day course and 800mg for 7_day course in treatment of uncomplicated falciparum malaria has been done in drug_resistant malaria epidemic area of Hainan island, China. Fifty patients were observed in each group and all patients were hospitalized for 28 days.The results showed that all patients were clinically cured.In 5_day and 7_day groups, the mean fever subsidence times(FST) were (24.0±13.6)and (20.0±10.0)hrs and the mean parasite clearance times(PCT) were(61.7±21.1) and (55.8±15.8) hrs respectively, the differences being not significant. In 28 days, the recrudecence rate and curative rate were 4.2%(2/48)and 95.8% in 7_day group, while 19.1%(9/47) and 80.9% in 5_day group respectively, the differences being significant (χ2=5.20,P<0.01).Patients in this area were mostly non_immune to malaria, this may explain the relatively high recrudescence rate in 5_day regimen and an obvious decrease in 7_day regimen. No clinical side effect was found in two groups.It is suggested that artesunate 800mg for 7_day course is a regimen with high curative rate and can be used as a standard dose and a criterion for monitoring sensitivity in vivo.
出处
《广州中医药大学学报》
CAS
1998年第2期81-83,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
国家中医药管理局科研基金
关键词
疟疾
药物疗法
青蒿素
青蒿琥酯
MALARIA, FALCIPARUM/drug ther.
PLASMODIUM FALCIPARUM/drug eff.
ARTEMISININ/ther.use
ARTEMISININ/analogs
@ARTESUNATE/ther.use