电活性聚膦腈生物材料的合成及表征

Synthesis and Characterization of a Novel Electro-active Polyphosphazene Biomedical Material

通过热开环聚合方法,合成了聚二氯膦腈,再利用亲核取代反应合成了含导电基团苯胺四聚体的聚膦腈。采用核磁共振、红外、紫外可见光谱、循环伏安法等对聚合物的结构和性能进行了表征;体外细胞实验采用RSC96永生化雪旺细胞测试材料的生物相容性。结果表明,聚合物的分子量为-Mw=2.1×105,-Mn=6.2×104,分子量分布d=-Mw/-Mn=3.38;聚合物具有优良的成膜性能和溶解性能;经质子酸掺杂后的聚合物具有一定的电活性;材料与RSC96细胞生物相容性良好,能够显著地促进细胞的分化和增殖。这种新型材料的合成方法为生物医用材料的合成提供了一条新途径。

Reactive polymer-poly（dichloro）phosphazene was prepared from hexachlorocyclotriphosphazene by thermal initiated ring-open polymerization. Then a novel Electro-active polyphosphazene containing tetraaniline group and methylphenol group was synthesized by nucleophilic reaction. The chemical structure and properties of the polymer were characterized by IHNMR, FT-IR, UV-Vis and Cyclic voltammetry. RSC96 Schwann cells were used for the biocompatible assessment of the assynthesized polymer in vitro. The as-synthesized polymer shows good solubility in common organic solvent and good film-forming properties. After doped with protonic acids, the polymer exhibits excellent electro activity. RSC96 Schwann cells experiments in vitro proved the polymer good biocompatibility with the cells and is helpful to cell adhesion and migration. This new type of electro-active polyphosphazenes provides a favorable prospect in biomedical application.