血浆孤啡肽水平与心功能关系的初步研究

An initial research of the relationship between plasma OFQ levels and heart function

为探讨充血性心力衰竭(CHF)患者血浆孤啡肽(OFQ)变化的临床意义,用放射免疫法测定了35例CHF患者和26例健康人血浆OFQ含量。结果表明:CHF患者血浆OFQ水平明显增高(16.20±0.87ng/L),较对照组(8.19±0.43ng/L)增加了约2倍(P<0.001);血浆OFQ含量与引起CHF的病因无关,而与CHF严重程度相平行,并发现与左室射血分数(LVEF)呈显著负相关(r=-0.84,P<0.001)。14例CHF患者经治疗好转后血浆OFQ含量下降(由15.96±1.43ng/L降至10.15±0.54ng/L,P<0.001)。提示OFQ在CHF的发病过程中可能具有一定作用。

Plasma orphanin FQ(OFQ) was measured by radioimmunoassay in 35 patients with Congestive heart failure (CHF) and 26 healthy control subjects. The results showed that plasma OFQ levels were elevated in patients with CHF compared with control subjects (16.20±0.87ng/L vs 8.19±0. 43ng/L,.P<0. 001). There was no obvious relation between the plasma OFQ levels and the causes of heart failure, but there was a close relationship between the severity of CHF and the plasma OFQ levels. The severer the CHF, the higher the OFQ Level. Left ventricular ejection fraction was inversely correlated with the plasma OFQ levels (r=-0. 84,P<0. 001). The plasma OFQ levels of 14 of the 35 patients were significantly decreased as symptoms improved after treatment (from 15.96±1.43ng/L to 10.15±0.54ng/L,P<0. 001). These results suggest that OFQ might play a certain role in the pathophysiology of CHF.