菟丝子多糖复合羟基磷灰石局部植入对兔骨缺损修复的影响

Effect of Compounds of the Polysaccharide from Cuscuta and Hydroxyapatite Ceramic on the Repair of Bone Defect in Rabbits

目的:研究菟丝子多糖复合羟基磷灰石在促进兔骨缺损修复中的价值。方法:日本大耳白兔76只,随机分为实验组Ⅰ、实验组Ⅱ和模型组。行桡骨缺损造模后,实验组Ⅰ在缺损处植入菟丝子多糖-羟基磷灰石复合物,实验组Ⅱ在缺损处植入骨形态发生蛋白-羟基磷灰石复合物,模型组只造模不植入,分别在术后2、4、8周对实验组Ⅰ、实验组Ⅱ和模型组行抗折力学测试及骨痂重量检测。结果:术后4、8周,实验组Ⅰ与实验组Ⅱ之间的抗折力学测试结果无差异(P>0.05);术后2、4、8周,实验组Ⅰ与实验组Ⅱ之间的骨痂重量无显著性差异(P>0.05);术后4、8周,实验组Ⅰ、实验组Ⅱ的骨痂重量均大于同期实验组Ⅱ(P>0.01,P>0.05)。结论:菟丝子多糖复合羟基磷灰石局部植入能促进兔桡骨缺损修复。

Objective： To research the significance of the compounds of the polysaeeharide from Cuscuta and hydroxyapatite ceramic in the repair of bone defect.Methods： Made the bone defect models in fight radial bones of 76 rabbits, implanted compounds of the polysaecharide from Cuscuta and hydroxyapatite ceramic with the experimental Ⅰ group and the experimental Ⅱ group in the vitodynamies tests and the weight of bony callus by the end of each weeks （ P 〉 0.05） . The experimental Ⅰ group showed a better result in the weight of bony callus contrasted with the sham group by the end of the 4th and 8^th weeks （ P 〈 0.01 ） .The experimental Ⅱ group also showed a better result in the weight of bony callus contrasted with the sham group by the end of the 4^th and 8^th weeks （ P 〈 0.05）. ConcluSion： The polysaecharide from Cuscuta combined with hydrexyapatite ceramic has a valid recovery effect in the repair of the rabbit＇ s bone defect.