穿破石总黄酮对两种肝纤维化模型大鼠的实验研究

Effect of TFC on Two Kinds of Liver Fibrosis Model in Rat

目的:研究穿破石总黄酮对两种肝纤维化模型大鼠的影响。方法:Wistar大鼠分为不同浓度给药组、模型组和空白组。采用两种肝纤维化模型造模,同时给药。8周后,取大鼠血清测ALT和AST,并检测肝脏MDA、SOD的含量。结果:穿破石总黄酮能降低化学损伤模型大鼠血清中ALT和AST的活性,增加SOD活性,抑制MDA的生成。但只提高免疫型肝纤维化模型大鼠的SOD活性。结论:穿破石总黄酮可减轻CCl4所诱导化学损伤的肝纤维化模型大鼠肝损伤程度。

Objcective： To find out the effect of TFC on rat which were in different liver fibrosis.Methods： Wistar rat were divided into three groups： control group, model group, group treated with TFC.While deal with two models, gave rat total flavones i.g.After 8 weeks, serum of rat was examined for ALT and AST, live preparation was tested for the levels of MDA and SOD.Result： In groups which was induced by CCl4, TFC cut down the levels of ALT, AST and MDA, increased the activity of SOD： But can do nothing except increased the activity of SOD in groups which was induced by serum of pig. Conclusion： TFC can mitigate the liver damage of rat which was induced by CCl4.