摘要
目的：观察茶色素预防心肌再梗死的临床疗效。方法：将９６８例急性心肌梗死患者随机分为茶色素预防组４８６例和阿斯匹林预防组４８２例。茶色素组患者自住院后急性期开始服用茶色素胶囊１２５ｍｇ，每日１次，出院后继续服用，门诊观察；阿斯匹林组患者口服阿斯匹林片０．３ｇ，每日１次，应用方法同茶色素。结果：在２组男性患者中均明显降低再梗死的发生，２组比较无显著性差异，而在女性患者中，茶色素组较阿斯匹林组发生再梗死者明显减少，时序检验Ｐ＜０．００１；２组患者死亡例数均减少，差异无显著性；预防治疗后茶色素组两性患者及阿斯匹林组男性患者血小板聚集性明显受抑制，纤维蛋白原、全血比粘度及血浆比粘度均明显下降，Ｐ均＜０．０１，阿斯匹林组女性患者上述几项指标均无明显下降，Ｐ均＞０．０５。预防治疗后，２组男性患者比较无显著性差异，Ｐ均＞０．０５，而女性患者比较则差异显著，Ｐ均＜０．０１。
Objective:To observe the clinical therapeutic efficacy of tea pigment in prevention of myocardial reinfarction.Methods:Nine hundred and sixtyeight cases of acute myocardial infarction were divided randomly into tea pigment group (n=486) and aspirin group (n=482).The tea pigment group was treated with oral 125 mg tea pigment capsule once every day;the aspirin group was treated with oral 03 g aspirin once every day.Results:The incidence of male myocardial reinfarction cases was decreased in both groups,while there was no statistical difference.The incidence of female myocardial reinfarction cases was lower significantly in tea pigment group than those in aspirin group (P<0001).Mortality,either male or female patients,was decreased in both groups,but no significant difference between 2 groups.Patient′s hemorrheologic change was showed that the aggragation of platelet was inhibited,the value of fibrinogen,blood viscosity and plasma viscosity were decreased obviously either male or female cases in tea pigment group and male cases in aspirin group (all P<001),while no changes in those parameters of female cases in aspirin group (all P>005).After preventive treatment,there was no obvious difference in male cases between 2 groups (all P>005),while obvious difference in female patients between 2 groups (all P<001).Conclusions:Tea pigment can decrease obviously the incidence of myocardial reinfarction either male or female patients.
