NK细胞趋化因子和细胞因子的分泌与调节

Secretion of cytokines and chemokines by NK cells and regulation

NK细胞是固有免疫系统中一个非常重要的成员，能够杀死病毒、细菌、寄生虫感染的细胞以及肿瘤细胞。同时，NK细胞也可以分泌一些细胞因子和趋化因子来调节免疫应答以及炎症反应，然而，这种分泌功能与NK细胞的成熟状态相关，同时也受到一些调控因子的调节，比如P1108，深入研究这些因子的功能和调控过程，对NK细胞参与免疫应答以及炎症反应具有重要意义。

Natural killer （NK） cells are the important members involved in innate immunity, which can kill virus-, intracellular bacteria-, and parasite-infected target cells or tumor cells. NK cells can secrete cytokines/ chemokines as well, in order to mediate immune response and inflammation. However, its eytokine-secretion ability is related with the maturation of NK cells and is regulated by some factors, for example, P110δ. There-fore, more work should be done to elucidate the function and regulation of these factors, which have a significant influence on inflammation and tissue impairment in some diseases involving NK cells.