茶多酚与阿司匹林对高血压及冠心病患者前列环素和血栓素的影响——附85例临床分析

Comparison of the effects of tea polyphenol and aspirin on prostacyclins in patients with hypertension and coronary heart disease: clinical analysis of 85 cases.

目的：观察茶多酚对高血压及冠心病患者血浆前列环素及血栓素的影响。方法：将５９例高血压和２６例冠心病病人随机分为两组，分别予茶多酚３００ｍｇ每日３次和阿司匹林８０ｍｇ每日１次口服治疗。结果：治疗前后的自身对照，两组的血浆血栓素Ｂ２水平降低（Ｐ＜０．０５，Ｐ＜０．０１），６－酮－前列腺素Ｆ１α／血栓素Ｂ２比值升高（Ｐ＜０．０５），两组的作用相近；而６－酮－前列腺素Ｆ１α两组治疗前后比较均无明显变化（Ｐ＞０．０５）。对茶多酚组的２６例继续治疗２周后发现此药能进一步降低血浆血栓素Ｂ２水平，提示较长期治疗可能更有意义。结论：治疗２周后茶多酚和阿司匹林在降低血栓素Ｂ２、升高６－酮－前列腺素Ｆ１α／血栓素Ｂ２比值的作用是相近的。

Objective:To evaluate the effects of tea polyphenol on plasma thromboxane and prostacyclin levels in patients with essential hypertension and coronary heart disease.Methods:Fiftynine patients with hypertension and twentysix patients with coronary heart disease were divided into 2 groups randomly.In group 1,patients were given 300 mg tea polyphenol three times one day. In group 2,patients were given 80 mg aspirin daily.Results:After 2 weeks treatment,thromboxane B2 dropped and 6ketoprostaglandin F1α/thromboxane B2 ratio increased while 6ketoprostaglandin F1α changed little in both groups.Twentysix patients in group 1 were given another 2 weeks treatment.After 4 weeks,their thromboxane B2 were lower than those after 2 weeks.Conclusion:The effect of tea polyphentol and aspirin included reducing thromboxane B2,increasing 6ketoprostaglandin F1α/thromboxane B2 ratio at the nearly extend after 2 weeks treatment.The mechanism of tea polyphenol to inhibit platelet aggregation may be associated with reducing thromboxane B2.