脐带间充质干细胞的分离鉴定及肝病治疗的研究进展

Isolation, characterization and application of umbilical cord mesenchymal stem cells in the treatment of liver diseases

近几年来，脐带组织已经成为科研工作者们的研究热点。由于脐带为出生以后的废弃物，其细胞的收集没有侵袭性和伦理道德问题。人脐带间充质干细胞（UCMSCs）含量丰富、较为原始、分化能力强，可在体外进行分离、培养，扩增迅速且生物性能稳定，多次传代扩增仍能保持旺盛功能，免疫原性低。国内外研究表明MSCs具有直接或间接的抗炎、抗纤维化、抑制肝细胞凋亡、刺激肝细胞再生的作用，因此脐带间充质子细胞可作为肝脏疾病细胞治疗的理想的靶细胞。

Human umbilical cord （UC） has been attracting increasing research effort in recent years.Since UC is a postnatal organ discarded after birth, the collection of its cells is non-invasive and raises no ethical concerns.Human umbilical cord provides large amount of mesenchymal stem cells（MSCs） which hold unlimited capability of proliferation and great potential of differentiation and. MSCs have stable biological properties and lower immunogenicity and can function well after amplifications.Studies have demonstrated that MSCs have the potential of inhibiting inflammatory response, generation of fibrosis, apoptosis and stimulating regeneration of hepatocytes.Therefore, UCMSCs could be an ideal cell source for the therapy of liver diseases.