102例临床移植供受者HLA分型的回顾分析

Retrospective analysis of HLA typing in 102 clinical transplantation recipients and donors

目的：分析102例供受者HLA-Ⅰ类抗原分布，供受者HLA-Ⅰ类抗原全相合和半相合的机率及移植结果。方法：微量淋巴细胞毒试验。结果：27名患者及其75名家属HLA-A，B位点抗原分布与汉族人类似，同时有一定地域性。15名患者有全相合供者，55人能提供半相合的骨髓。其中3例异体外周血干细胞移植（PBSCT）全部存活；16例半相合混合骨髓移植（MBMT）中，7例无病存活，8例发生慢性移植物抗宿主病（cGVHD）。结论：多数患者有HLA半相合乃至全相合的供者，MBMT或PBSCT能挽救部分患者生命。

Objective: Analysis the antigen frequencies of HLA -A, B loci of 25 patients with bind disease and 75 their close relatives and examination the numbers of whom HLA are identical and haploidentical. Method: Microdroplet lymphcyte cytotoxicity test. Results : Frequencies of HLA -A, B antigen are somilar to Han nationality and shows some regieon characteristic. 7 potents were disease -bee alive and 8 patients courred chronic ed versus host diseas(GVHD) after mixed bone marrow transplantation(MBMT) in all 16 patients. 3 Allo- peripheral blood stem cell transplantation (PBSCT) patients are all alive. Conclusion: over half of patients have HLA identical or haploidentical donors. MBMT and PBSCT can revive some patients.