高水碘摄入与血脂异常流行病学关联的探索性研究

Exploratory study on the association between high iodine intake and lipid

目的初步探索饮水高碘摄入是否与人群血脂异常存在流行病学关联。方法2006年国家碘缺乏病国际合作技术指导中心在江苏省徐州市睢宁地区的水碘抽样调查基础上，以各居民户水碘含量为线索，筛选高碘饮水居民81人和适碘饮水居民101人，采集静脉血。比较高碘组和对照组居民血脂（TG、TC、HDL-C、LDL-C、apoA1、apoB）水平，并利用分层分析排除年龄、性别的影响；比较两组居民各血脂指标异常检出率，得到相应高碘组血脂异常的RR值及其95％C1，分析居民饮水碘含量与居民血脂指标的相关关系。结果高碘组居民血清中apoA1水平显著低于对照组，其余血脂指标水平两组间的差异无统计学意义；高碘组HDL-C过低异常率（16．88％）显著大于对照组异常率（7．22％），其余血脂指标异常率两组间的差异无统计学意义；高碘组居民血清apoA1、HDL-C与饮水中碘含量呈负相关，对照组居民血清中各血脂指标与饮水水碘含量均无显著相关。结论饮用高碘水可能使血脂异常的风险增加。

Objective To explore the association between excessive iodine intake and lipid disorder in human bodies. Methods Based on the NTTST sample survey on water iodine in Suining of Jiangsu province, this study involved 81 residents whose drinking water containing excessive iodine and 101 residents who drank water with normal iodine content. Blood samples were tested and compared on lipids （TG, TC, HDL-C, LDL-C, apoA1, apoB） between the two groups, after adjusting the influences of age and gender. The study also compared the abnormal rate of each lipid indicator between the two groups. Corresponding RR values and 95% confidence interval were calculated. Correlation between iodine content in drinking water and blood lipid was also studied. Results apoA1 in the group with excessive iodine intake was significantly lower than that in the normal iodine group, while there were no significant differences between the two groups in other lipid indicators. The abnormal rate of HDL-C of excess iodine group （16.88%） was significantly higher than the rate of normal iodine group （7.22%） while there were no significant differences between the two groups in other lipid indicators. Both apoA1 and HDL-C in the excess iodine group had a negative correlation with water iodine, while the other indicators of two groups had no correlation with water iodine. Conclusion Drinking water with excess iodine might increase the risk of lipid disorder.