CYP4F2基因单体型与心肌梗死的相关性研究

Association on the haplotypes of CYP4F2 gene and myocardial infarction

目的研究CYP4F2基因单体型与心肌梗死的关系。方法250例心肌梗死患者和250例对照分别分为整体组、男性组、女性组。选择CYP4F2基因的5个SNPs（rs3093105、rs3093135、rs1558139、rs2108622、rs3093200），应用TaqManSNP基因分型方法进行基因分型，并应用病例对照单体型分析方法进行相关性研究。结果对于男性，心肌梗死患者rs2108622的G等位基因频率远远高于对照（P=0．005）；心肌梗死患者和对照相比较，单体型的总体分布在男性组显著不同（P=0．002）；男性组心肌梗死患者的T-C-G单体型频率显著高于对照（P=0．002），男性组心肌梗死患者的T-C—A单体型频率显著低于对照（P=0．003）。结论CYP4F2基因rs2108622的G等位基因可能与男性心肌梗死相关，T-C-G单体型可能是男性心肌梗死的遗传标记。

Objective The aim of this study was to assess the association between human CYP4F2 gene and myocardial infarction （MI）,using a haplotype-based case-control study. A separate analysis on gender was also carried out. Methods There were 250 MI patients and 250 control subjects genotyped for 5 SNPs of the human CYP4F2 gene （rs3093105, rs3093135, rs1558139, rs2108622, rs3093200）. Data were assessed on 3 separate groups： the total subjects, men and women. Results For men, G allele was significantly higher in the MI patients than in the control subjects and the overall distribution of the haplotypes was significantly different between the MI patients and the control subjects （P=0.002）. Also in men, the frequency of T-C-G haplotype was significantly higher for MI patients than for control subjects （P=0.002）, and the frequency of T-C-A haplotype was significantly lower for MI patients than for control subjects （P=0.003）. Conclusion Data from the present results indicated that MI was associated with G allele of rs2108622 in men, suggesting that T-C-G haplotype might serve as genetic marker for MI in men.