AS、VEGF在胎儿生长受限患者脐血及胎盘部位的表达及意义

Expression of AS and VEGF in cord blood and placenta of FGR

目的通过检测脐血与胎盘部位血管生长抑素(angiostatin,AS)、血管内皮生长因子(vascular endotrelial growtr factor,VEGF)的表达,探讨其与胎儿生长受限(fetal growth restriction,FGR)发病的关系。方法取80例产妇(正常妊娠组50例,FGR组30例)分娩后采脐血和胎盘绒毛组织,检测AS、VEGF在脐血中的水平及其在胎盘部位的表达。结果①脐血中:在FGR组AS平均水平显著高于对照组(P<0.05);VEGF平均水平显著低于对照组(P<0.05)。②胎盘中:在FGR组绒毛滋养细胞AS的表达强度较正常对照组显著增强(P<0.05),而VEGF的表达降低,差异有统计学意义(P<0.05)。结论血管生长抑素(AS)与血管内皮生长因子(VEGF)浓度的变化可能在胎儿生长受限(FGR)的发病中起重要作用。

Objective： To investigate the expression of AS and VEGF in cord blood and placenta of FGR. Methods： The expression of AS and VEGF in cord blood and placenta was determined after delivery. The study group was divided into two groups ： the normal late pregnant group （ n = 50 ） ; the FGR group （ n = 30）. Results ： （ 1 ） The intensity of AS in FGR group was significantly higher than that of the normal early pregnancy （ P 〈 0. 05） ; but the intensity of VEGF in FGR group was lower than that of the normal early pregnancy （ P 〈 0.05） ; （2） The intensity of AS immunostaining of trophoblasts in FGR group was significantly higher than that of normal late pregnant group （ P 〈 0. 05 ） ; But the intensity of VEGF immunostaining of syncytiotrophoblasts in FGR group was lower than that of the normal late pregnant group （ P 〈 0. 05）. Conclusion ： The expression of AS and VEGF was correlated with the state of FGR.