摘要
目的研究绵萆薜Dioscorea septemloba的化学成分。方法用乙醇提取,石油醚、醋酸乙酯萃取,反复硅胶柱色谱技术分离纯化,根据理化性质,气质联用分析和光谱数据比较鉴定化学结构。结果分离得到13个化合物,分别鉴定为4,8-二甲基-1,7-壬二烯(Ⅰ)、5-异丙基-2,8-二甲基环癸酮(Ⅱ)、3,7-二甲基-6-辛烯-1-醇甲酯(Ⅲ)、十二酸甲酯(Ⅳ)、N,N″二硝基-1,2-环己二胺(Ⅴ)、1-辛炔-4醇(Ⅵ)、β谷甾醇(Ⅶ)、棕榈酸(Ⅷ)、豆甾醇(Ⅺ)、6,7-二羟基-2-甲氧基-1,4菲二酮(X)、薯蓣皂苷元(Ⅺ)、鲁可斯皂苷元(Ⅻ)、豆甾醇-3-O-β-D-葡萄糖苷(Ⅷ)。结论化合物Ⅰ~Ⅵ、Ⅸ、Ⅹ、Ⅶ、Ⅷ均为首次从该植物中分离得到。
Objective To study the chemical constituents of Dioscorea septernloba. Methods The com- pounds were isolated by GC-MS and chromatography on silica gel column and identified on the basis of physico-chemical constants and spectral analysis. Results Thirteen compounds were isolated and their structures were identified as 4, 8-dimethyl-1, 7-nonadiene ( Ⅰ ), 5-isopropyl-2, 8-dimethylcyclodeea ( Ⅱ ), 3, 7-dimethyl-6-octen-1-ol-formate ( ), dodecanoic acid methyl easter (IV), N, N'-dinitro-1, 2 cyclo- hexanddiamine ( Ⅴ ), 1-octyn-4-ol ( Ⅵ ), β-sitosterol ( Ⅶ ), palmitic acid ( Ⅷ ), stigmasterol ( Ⅸ ), 6, 7- dihydroxy-2-methoxy-1, 4-phenanthrenedione ( Ⅹ ), diosgenin (Ⅺ), ruscogenin ( Ⅶ ), and stigmasterol- 3-O-β-D-glueoside (Ⅷ). Conclusion Compounds Ⅰ--Ⅵ,Ⅸ, Ⅹ ,Ⅶ , and Ⅷ are obtained from this plant for the first time.
出处
《中草药》
CAS
CSCD
北大核心
2009年第7期1024-1026,共3页
Chinese Traditional and Herbal Drugs
基金
吉林省科技厅重点项目(20050909)