泛昔洛韦治疗带状疱疹疗效观察

Observation on the Clinical Efficacy of Famciclovir for Herpes Zoster

目的回顾和探讨泛昔洛韦治疗带状疱疹的近期疗效。方法2002年1～12月陆续就医我院的144例带状疱疹患者随机设为治疗组和对照组。并对所有病例进行为期4用的临床观察。治疗组74例,口服泛昔洛韦0.25,3次/d×7d。维生素B120mg3次/d×7d。疼痛剧烈者加服苯乐来0。5,3次/d×7d。所有病例均外擦酞丁胺擦剂。对照组70例口服阿昔洛韦0.4,5次/d×7d,余同前。运用(±s,n=144)进行统计学处珲和分析。结果发现治疗组在止疱,结痂,脱痂,疼痛缓解及疼痛消失的时间均较对照组快,后遗神经痛较少,经统计学处理P<0.01。结论泛昔洛韦治疗带状疱疹疗效明显优于阿昔洛韦。

Objective To evaluate the short--term clinical efficacy of famcicovir in the treatment of herpes zoster. Methods From January 2002 to December,ira our department 144 patients suffering from herpes zoster were randomly divided into treatment group and control group. The course of treatment and observation was 4 weeks. 74 patients in treatmenl group received famciclovir 250mg,Vitamin B1 20mg by oral administration, three times a day and 70 patients in control group received acyclovir 400mg by oral administration,five times a day. Phthiobuzone liniment was used by all patients and benorilate was used W,hen severe pain was occured. Results The regression time of the pain and herpes in the treatment group Was significantly shorter than that of the control group as well as the time of incrustation and decrustation（P〈0.01）.The incidence rate of residual neuralgia in the treatment group was significantly lower than that of the control group.Conclusion Famciclovir has significantly therapeutic effect in the treatment of herpes zoster than acyclovir.