肝硬化患者血清Ⅲ型前胶原水平及其与HBVe抗原抗体的关系

A Study of the Relationship Between Serum ProcollagenⅢ and anti-HBeAg Antibody of Patients with Liver Cirrhosis

目的：了解肝硬化患者血清Ⅲ型前胶原（ＰＣⅢ）水平及其与ｅ抗原抗体的关系。方法：采用放免法检测７１例慢性乙型肝病患者（慢迁肝３４例，肝硬化３７例）血清ＰＣⅢ水平。结果：慢迁肝组血清ＰＣⅢ水平为１１６．７±２０．５μｇ／Ｌ，与对照组比较无显著性差异（Ｐ＞０．０５）；肝硬化组血清ＰＣⅢ水平为１５８．６±４２．６μｇ／Ｌ，与对照组比较差异显著（Ｐ＜０．０５）。肝硬化组中，ＨＢｅ－Ａｇ阳性亚组和抗ＨＢｅ阳性亚组血清ＰＣⅢ分别是１３３．９±２０．２μｇ／Ｌ和１７２．９±５２．４μｇ／Ｌ，二者比较有显著差异（Ｐ＜０．０５）。结论：血清ＰＣⅢ水平检测对肝硬化有一定诊断价值；

Objective:To explore if there is a relationship existed Between the serum ProcollagenⅢ(PCⅢ)level in lives cirrosis and anti-HBeAg antibody.Method:Serum PCⅢ levels of chronic patients with viral hepatitis B( n =71;37 cases of liver cirrhosis and 34 cases of chronic progressive hepatitis CPH)were assayed with radioimmunoassay.Results:Levels of serum PCⅢ were 116.7±20.5μg/L for CPH, didnt show obvious discrepancy compared to that of the control(104.4±17.9μg/L);158.6±42.6μg/L for liver cirrhosis,which showed significant difference compared to that of the control( P <0.05).Of the liver cirrhosis group,the serum PCⅢ for HBeAg positive subgroup and and that for anti HBe positive subgroup were 133.9±20.0 μg/L and 172.9±52.2 μg/L respectively, showing marked difference( P <0.05).Conclusion:Examination of serum PCⅢ level has some diagnostic value for liver cirrhosis;the trend of liver fibrosis for patients with chronic liver diseases accompanied by anti HBeAg positive findings should be taken into account in the clinics.