血清Ⅲ型前胶原对肝纤维化的诊断价值

Significance of serum procollagen type Ⅲ in the diagnosis of hepatic fibrosis

应用放射免疫法（ＲＩＡ）检测１４９例各种肝病患者血清Ⅲ型前胶原（ＰＣⅢ）含量，并以４０例正常人及２５例非肝病患者为对照。结果表明，各肝病组（除慢迁肝外）血清ＰＣⅢ均显著高于正常对照及非肝病组（Ｐ＜０．０５），其中以慢活肝、肝硬化及硬化型肝癌组升高最为显著。血清ＰＣⅢ升高水平与肝组织中的纤维细胞数和纤维化程度相关显著（γ＝０．５８２，Ｐ＜０．０５），而与小叶内坏死及炎性细胞浸润不相关（ｒ＝０．１５９，Ｐ＞０．０５）。提示血清ＰＣⅢ水平可反映肝纤维化程度。

Serum procollagen type Ⅲ(PCⅢ)concentrations of 40 normal controls,149 patients with varied liver diseases and 25 non-hepatic diseases were measured by radioimmunoassayThe results showed that PCⅢ levels were elevated in all of the patients with varied liver diseases except chronic persistent hepatitisHowever,the levels were highest in those with chronic active hepatitis and hepatic cirrhosisThe raised serum PCⅢ in patients with chronic liver cliseases did not correlate with standard liver function tests and histological parameters of inflammation and necrosis,but correlated well with the degree of fibrosis (r=0582,P < 005),The results suggested that the determination of serum PCⅢ is valuable in the diagnosis of hepatic fibrosis \ \