比索洛尔对左心室射血分数正常的老年心力衰竭患者脑钠肽水平的影响

Effects of bisoprolol on B-type natriuretic peptide level in old heart failure patients with normal LVEF

目的观察选择性β_1受体阻滞剂比索洛尔治疗LVEF正常的老年心力衰竭患者疗效和安全性。方法选择40例LVEF正常的老年心力衰竭患者服用比索洛尔2.5～5 mg/d,共8周。治疗前后测患者心率、血压、血浆B型钠尿肽(BNP)、心房钠尿肽(ANP)、利钾尿肽(KP)、肝肾功能、血糖和血脂水平。记录药物不良反应。结果与治疗前比较,40例患者治疗8周后,心率、血压均显著降低,差异有统计学意义(P<0.01);血浆BNP、ANP及KP水平均显著下降,差异有统计学意义(P<0.01)。治疗前后40例患者肝肾功能、血糖和血脂等指标均无明显变化(P>0.05)。结论比索洛尔能有效治疗LVEF正常老年心力衰竭患者,且无明显不良反应,患者依从性良好。

Objective To observe the efficacy and safety of bisoprolol in treatment of heart failure with normal LVEF in older patients. Methods Forty patients were given 2.5--5 mg/d bisoprolol for 8weeks. Heart rate, blood pressure, B-type natriuretic peptide （BNP） level, atrial natriuretie peptide（ANP） level, kaliuretic peptide （KP） level, hepatic function, renal function, blood glucose and lipid were measured before and after treatment. Adverse events were recorded. Results After the treatment,heart rate,blood pressure,plasma BNP,ANP and KP levels were decreased （P 0.01）. Hepatic function,renal function, blood glucose and lipid did not change significantly after treatment. Conclusions Bisoprolol can effectively treat heart failure with normal LVEF in older persons, with good compliance and no obvious adverse events.