低剂量激素替代治疗对绝经后妇女糖代谢的影响

EFFECTS OF LOWDOSE HORMONAL REPLACEMENT THERAPYON GLUCOSE METABOLISM IN POSTMENOPAUSAL WOMEN

目的探讨低剂量激素替代治疗（ＨＲＴ）对绝经后妇女（ＰＭＷ）糖代谢的影响。方法将３０例ＰＭＷ随机分为两组，口服结合型雌激素（ＣＥ）０．６２５ｍｇ与安宫黄体酮（ＭＰＡ）２ｍｇ隔日交替应用１６例为试验组；口服ＣＥ０．６２５ｍｇ／ｄ，每月连服２５ｄ。后１０ｄ加服ＭＰＡ２ｍｇ１４例为对照组。两组均连用４个周期，治疗前后各测定空腹血糖水平。结果两组治疗效果组间比较无显著差异（Ｐ＞０．０５）；而治疗前和治疗后空腹血糖水平比较均有显著差异（Ｐ＜０．０５）。结论低剂量ＨＲＴ可有效降低ＰＭＷ的空腹血糖水平，从而对防治心血管疾病具有较高的临床价值。

Objective To study the effects of lowdose hormonal replacement therapy 4(HRT) on glucose metabolism in postmenopausal women.Method 30 cases of postmenopausal women(PMW) were divided randomly into trail (16 cases) and control group (14 cases). The train group received lowdose estrogen and progestogen: conjugated estrogen(CE) 0.625mg and medroxyprogesterone acetate(MPA) 2 mg QOD alternately. The control group was treated with CE 0.625 mg daily for 25 days in combination with cycle MPA 4 mg daily ,the last 10 days for four cycles.Fasting plasma glucose concentrations were measured before and after treatment in all subjects.Result The levels of fasting plasma glucose were significanfly reduce in both of group(P<0.05);there were no significanfly in between the train group and the control group(P>0.05).Conclusion The lowdose hormonal replacement therapy may significanfly reduce the levels of fasting plasma glucose and reduced risk of cardiovascular disedse.