对Ⅱ型糖尿病病人胃泌酸功能改变的观察

An evaluation of function of gastric secretive acid in NIDDM

对３４例ＮＩＤＤＭ病人进行了胃液分析，结果表明，糖尿病病人比正常对照组游离酸和总酸降低，ｐＨ值增高。３４例糖尿病病人中有１９例ｐＨ＞３．０，显示糖尿病病人胃酸缺乏的发生率较高（５５．８％）。糖尿病病人中胃酸缺乏组与胃酸正常组相比，年龄、病程、空腹和餐后胰岛素水平无显著性差异（Ｐ＞０．０５）。而空腹和餐后血糖水平、ＨｂＡ１ｃ、肾脏、眼底和自主神经病变发生率明显增高（Ｐ＜０．０５）。说明血糖控制不良。

Gastric juice was assayed in 34 patients with NIDDM.The results showed that free acid and total acid were decreased while pH was increased significantly in diabetic groups as compared with healthy control group.pH>3.0 in 19 cases of 34 diabetic patients.Incidence of hypoacidity was high in diabetes mellitus patients (55.8%).Age, course,fasting and postprandial serum insulin level were no significant difference between diabetic patients with hypoacidity and nomal acidity in gastric fluid (P>005).Fasting and postprandial glycemic level,hemoglobin,diabetic nephropathy,diabetic retinopathy,autonomic neuropathy were increased significantly in patients with hypoacidity of gastric fluid as compared with in patients with nomal acidity (P<005).These data indicated poor glycemic level control,leads to widespread vascuto pathy,autonomic neuropathy and is the high rish factors with hypoacidity in NIDDM.