曲美他嗪联合氯吡格雷治疗不稳定型心绞痛的临床观察

Efficacy of Trimetazidine plus Clopidogrel for Unstable Angina Pectoris

目的:探讨曲美他嗪联合氯吡格雷治疗不稳定型心绞痛的临床疗效。方法:将100例不稳定型心绞痛患者随机分为观察组和对照组各50例,对照组采用常规治疗方法,观察组在常规治疗方法的基础上加用曲美他嗪和氯吡格雷。在治疗8周后分别对两组临床疗效、不良反应、心电图及动态心电图变化进行对比分析。结果:观察组患者在心绞痛有效控制率、心电图改善情况、动态心电图缺血发作次数、总缺血时间上明显好于对照组,差异存在显著性,P<0.05。结论:曲美他嗪联合氯吡格雷治疗不稳定型心绞痛临床疗效好、无明显不良反应,值得临床应用推广。

OBJECTIVE： To evaluate the curative efficacy of trimetazidine plus clopidogrel for unstable angina pectoris. METHODS： 100 patients with unstable angina pectoris were randomly assigned to receive conventional therapy alone （control group, n= 50） or conventional therapy plus trimetazidine and clopidogrel （trial group, n = 50）. After treatment for 8 weeks, the clinical efficacy, adverse drug reactions （ADRs） and the changes in ECG and dynamic electrocardiogram （DCG） were compared between two groups. RESULTS ： The effective control rate of angina, ECG, the occurring times of ischemia in DCG, the total ischemic duration in the trial group had a better improvement than in the control group, showing significant differences between the two groups （ P 〈 0.05）. CONCLUSION ： Trimetazidine plus clopidogrel has satisfactory therapeutic efficacy for unstable angina pectoris yet without adverse drug reactions, which thus deserving to be used widely in clinical practice.