SLE临床分型及免疫调节治疗效果分析

Study of clinical subclassification and individualized immunoregulatory therapy of SLE

目的：研究SLE病人免疫调节细胞异常与临床表现的关系，指导临床制订个体化的免疫调节治疗。方法：用流式细胞仪检测30例正常人及64例SLE病人外周血两种主要免疫调节T细胞在应用糖皮质激素及免疫抑制剂治疗前后的变化。结果：CD4／CDS比值（TR）的变化与病人临床特征密切相关，据此将病人划分为3个临床亚型，经糖皮质激素调节治疗一个月后，病人TR均达正常水平，而免疫抑制剂治疗使CD4+细胞减少，致TR下降。结论：糖皮质激素有适应性免疫调节作用，适用于各型病人，而免疫抑制剂更适用于CD4+细胞数及TR均高者。

Objective: To study the immunoregulatory abnormality and it'S correlation with clinical featuresof SLE so as to design the individualized immunoregulatory therapy clinically. Metheds:The percentage Of 2 major immunoregulatory T cells (CD4+,CD8+ ) were detected in 30 normal subjects and 64 SLE patients after corticosteroid and inununosuppressor therapy with flowcytometry. Results:CD4+/CD8+ ratio (TR) closely correlated with clinical features of SLE. Three clinical subtypes were classified according to TR and clinical features.TR of all SLE patients reached. normal level after corticosteroid therapy. Immunosupperssor therapy led to thedecrease of CD4+ T cell and TR. Coneclusion: Corticosteroid has adaptable immunoregulatory function and it isavailable to all 3 subtypes of SLE. Immunosuppressor should be used in the Patients with high TR and CD4+ Tcell Percentage.