一氧化氮治疗高原肺水肿前后的视网膜变化

CHANGES ON RETINA AFTER TREATMENT OF HIGH ALTITUDE PULMONARY EDEMA WITH NO

目的：观察ＮＯ（一氧化氮）在治疗急性高原肺水前后的视网膜的改变，为探讨高原缺氧性眼底疾病的防治提供理论依据；方法：采用直接眼底镜和血氧仪对２２例急性高原肺水肿患者在ＮＯ治疗前后（２４小时）进行眼底检诊和血氧测定；结果：２２例急性高原肺水肿患者眼底以动静脉血管改变为主（１００％）；其次发生程度不同的视乳头充血（９０．９％）、视网膜水肿（８１．８％）、渗出（１００％）及视网膜出血（１８．２％），ＮＯ吸入治疗后血管改变明显减轻（３６．３６％），乳头充血（２２．７２％）、网膜渗出（２７．２％）、网膜水肿及出血（９．０９）明显减轻或消失，与治疗前比较Ｐ＜０．０１；结论：ＮＯ对高原缺氧性视网膜改变有显著疗效。

 Objective:To study changes of retina after treatment of high altitude pulmnary edema(HAPE)with No and provide a theory basis to protect and cure retina disease at high altitude.Methods:Eyeground and SPO_2 of 22 patients with acute HAPE were measured using fundscope and palmoxi-meter before and after treating with NO.Results:All of 22 cases had eyeground changes(100%),the first change was of eyeground vessles(100%),the others were discus nervi opticihyperemia(909%),retina edema(818%) etc before treatment with NO.These conditions released or/and disappeared after treatment with NO(P<001).Conclusions:Significant effects of treatment are found in retina when NO is used to cure the acute HAPE.