摘要
转基因（transgene）和基因打靶（gene targeting）技术通过基因的加入或删除建立了大量小鼠模型，尤其是条件性基因敲除为避免小鼠突变体在胚胎期死亡提供了条件。本文主要以参与听觉机械转导、表达于盖膜和纤毛束上的基因及其小鼠模型为例，讨论该技术是如何揭示耳聋基因的存在、功能及其作用机制的。
出处
《国际耳鼻咽喉头颈外科杂志》
2009年第4期226-230,共5页
International Journal of Otolaryngology-Head and Neck Surgery
基金
德意志学术交流中心和中国国家留学基金管理委员会资助项目（2007[3030]）
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